Zhejiang Wu Yang Tang Pharmaceutical Co., Ltd.

Product Name

Grifola frondosa Extract

Grifola frondosa extract is a product completely present with active substances isolated and purified from grifola frondosa, a polypore mushroom that grows in clusters at the base of trees, particularly oaks. The mushroom is commonly known among English speakers as Hen-of-the-Woods, Ram's Head and Sheep's Head. In the United States' supplement market, as well as in Asian grocery stores, the mushroom is known by its Japanese name "Maitake", which means "dancing mushroom". The fungus is native to the northeastern part of Japan and North America, and is prized in traditional Chinese and Japanese herbology as a medicinal mushroom, an aid to balance out altered body systems to a normal level. Most Japanese people find its taste and texture enormously appealing.

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Nutrients

Maitake is rich in minerals (such as potassium, calcium, and magnesium), various vitamins (B₂, D₂ and niacin), fibers and amino acids. One active constituent in Maitake for enhancing the immune activity was identified in the late 1980s as a protein-bound beta-glucan compound.

Medicinal use and research

The underground tubers from which hen of the woods arises have been used in traditional Chinese and Japanese medicine to enhance the immune system. Researchers have also indicated that whole maitake has the ability to regulate blood pressure, glucose, insulin, and both serum and liver lipids, such as cholesterol, triglycerides, and phospholipids, and may also be useful for weight loss.

In 2009, a phase I/II human trial, conducted by Memorial Sloan�CKettering Cancer Center, showed Maitake could stimulate the immune systems of breast cancer patients.Small experiments with human cancer patients, have shown Maitake can stimulate immune system cells, like NK cells. In vitro research has also shown Maitake can stimulate immune system cells.An in vivo experiment showed that Maitake could stimulate both the innate immune system and adaptive immune system.

In vitro research has shown Maitake can induce apoptosis in cancer cell lines (human prostatic cancer cells, Hep 3B cells, SGC-7901 cells, murine skin carcinoma cells) as well as inhibit the growth of various types of cancer cells (canine cancer cells, bladder cancer cells).Small studies with human cancer patients, revealed a portion of the Maitake mushroom, known as the "Maitake D-fraction", possess anti-cancer activity.In vitro research demonstrated the mushroom has potential anti-metastatic properties. In 1997, the U.S. Food and Drug Administration (FDA) approved an Investigational New Drug Application for a portion of the mushroom.

Research has shown Maitake has a hypoglycemic effect, and may be beneficial for the management of diabetes. The reason Maitake lowers blood sugar is due to the fact the mushroom naturally contains a alpha glucosidase inhibitor.

Maitake contains antioxidants and may partially inhibit the enzyme cyclooxygenase.An experiment showed that an extract of Maitake inhibited angiogenesis via inhibition of the vascular endothelial growth factor (VEGF).